Nithsdale Wanderers from Crawick Holm in Sanquhar near Dumfries was a former Scottish football club which played in the Scottish League from 1923 to 1927. Originally formed in 1897, the club enjoyed a measure of local success in their early years. In season 1923–24 they were one of the clubs invited to join the Scottish League's new Third Division. Although this competition would exist for only three seasons and would have terrible economic consequences for many of its clubs, Nithsdale Wanderers were to thrive, albeit briefly, on their newfound status. In 1925, Wanderers won the Division Three championship. Although they finished comfortably mid-table in their debut season in Division Two, the 1926–27 season saw them finish bottom and have to seek re-election to the League (by this time Division Three was no more). They were unsuccessful and the brief League career of Nithsdale Wanderers was at an end. They continued to compete in local senior competitions, including the Southern Counties League and South of Scotland League, and occasionally qualifying for the Scottish Cup (suffering a 14–0 defeat against Dundee United in the 1931 competition). In 1951 the club dropped down to the junior grades, but continued to struggle, finally going out of existence in 1964.